A historical perspective of pancreatic cancer mouse models

Title: A historical perspective of pancreatic cancer mouse models
Creator: Colvin, Emily K.; Scarlett, Christopher J.
Relation: Seminars in Cell and Developmental Biology Vol. 27, p. 96-105
Publisher Link: http://dx.doi.org/10.1016/j.semcdb.2014.03.025
Publisher: Elsevier
Resource Type: journal article
Date: 2014
Description: Pancreatic cancer is an inherently aggressive disease with an extremely poor prognosis and lack of effective treatments. Over the past few decades, much has been uncovered regarding the pathogenesis of pancreatic cancer and the underlying genetic alterations necessary for tumour initiation and progression. Much of what we know about pancreatic cancer has come from mouse models of this disease. This review focusses on the development of genetically engineered mouse models that phenotypically and genetically recapitulate human pancreatic cancer, as well as the increasing use of patient-derived xenografts for preclinical studies and the development of personalised medicine strategies.
Subject: pancreatic cancer; mouse models; genetically engineered mouse models; patient-derived xenografts
Identifier: http://hdl.handle.net/1959.13/1067406
Identifier: uon:18398
Identifier: ISSN:1084-9521
Language: eng
Reviewed

		Thumbnail	File	Description	Size	Format